Macular Hole

A macular hole forms when there is traction on the macula from the vitreous that pulls the center of the macula enough to form a hole in the center of the vision.

What is a Macular Hole?

The macula is the center of your retina. It is responsible for your straight ahead vision. While reading the print on this page, you are using your macula. The cornea and lens in the front of your eye focus the image of these words onto your macula. The macula converts the light from the image on this page into a neurological signal that is processed by your brain. Since the very center of the macular is the thinnest part of the retina, it is also relatively weak. Some patients have an abnormally tight attachment between the vitreous gel that fills the eye and the center of the macula. When the vitreous gel contracts with aging, or after an injury, these people can develop a macular hole. Interestingly, 90% of macular holes occur in females. The reason for the female predilection for macular holes is unknown.

Macular Hole Stages

Macular holes are staged from 0 to 4. A stage 0 macular hole is not visible. It only shows up as a vitreous attachment at the center of the macula with optical coherence tomography scanning. Most eyes with stage 0 macular holes never develop a symptomatic macular hole. A stage 1 macular hole is not a full thickness macular hole. It forms when the center of the macula is tented upward from traction but a hole has not formed. Less than half of eyes with stage 1 macular holes develop a full thickness macular hole. Most of these eyes heal on there own. Stage 2 macular holes are small full thickness macular holes. Twenty percent of these holes will heal on there own. Most do not. Stage 3 macular holes are larger macular holes where the vitreous is still attached to the hole. Stage 4 macular holes are larger macular holes where the vitreous is not attached to the hole.

Macular Hole Spontaneous Closure

Small macular holes (Stage II) have about a 20 percent chance of spontaneously closing. The animated image with this text shows a macular hole that closed without surgery. Since macular hole surgery is never an emergency, it is sometimes worthwhile waiting a short time to see if a small macular hole will close on its own. When macular holes abort, or spontaneously close, the vision often returns all the way to normal over the course of about a year. There is often a small piece of tissue that can sit in front of the fovea, a pre-foveal opercula, that can block the vision. In the accompanying image, the patient took over a year for the pre-foveal opercula to pull free of the macula.

Macular Hole Surgery

Surgery is successful in closing macular holes that are less than 6 months old nearly 100 percent of the time. About 90 percent of macula holes close with one surgery. Some require multiple surgeries. Once a macular hole is closed, the vision improves some in 80 percent of eyes, a lot in 50% of eyes (to 20/40 or better), and to nearly normal in 10% of eyes (20/20). Even eyes with normal vision usually have some distortion in the vision for at least a year from the surgery. The risk of surgery is mostly that of retinal detachment (2%-10%), infection (0.01%) and bleeding (0.1%). Cataracts from in most eyes undergoing vitrectomy for any reason in patients over 50. Without surgery macular hole patients usually only lose the very center of their vision. The side vision stays good. Many older patients (85 and up) with a second good eye may decide not to have surgery for macular hole. To repair a macular hole, the surgeon first removes all the vitreous from inside the eye. This relaxes the edges of the macular hole. Many surgeons also do an internal limiting membrane peel further relaxing the edge of the hole. Then the patients eye is filled with gas. The gas pushes the hole closed like a draw bridge. In order for the gas to push on the hole, the patient must look toward the center of the earth after the surgery. Many different surgeons recommend different regimens. Most require a few days to a week of 90% face down positioning. There are pillows and message tables available in most cities for rent if patients want the extra help.

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Most patients with macular hole choose to have surgery. Macular holes over 6 months old can be closed, but the visual acuity results are not as good as they are for fresh holes. Even old holes, five to 10 years old, can be closed with surgery. In these situations there is about a 50% chance of improving vision.

Dr. Pautler's Blog on Macular Hole

Video Macular Hole Surgery without ILM Peel

This patient had a two month history of vision loss from a macular hole. The pre-operative OCT scan showed a stage II macular hole with a diameter of about 250 microns. The scan did not show a taught internal limiting membrane. This surgery is done with a short acting sulfur hexafluoride gas and no internal limiting membrane peel. The patient positioned for a week after surgery (Strict for 3 days). The hole closed and the vision has improved to 20/30 at 2 months.



Video Macular Hole Surgery with ILM Peel

Macular hole surgery in a patient with a stage 2 macular hole. The internal limiting membrane is peeled. A short acting gas was used (sulfur hexafluoride) and vision was 20/50 1 week after surgery. This surgery was done 1 month ago. Vision at 1 month visit was 20/40.



Macular Hole NEWS

Below are current articles from a Google News Feed on Macular Hole

VIDEO: Subthreshold laser shows favorable foveal remodeling after macular hole closure  Healio

VANCOUVER, British Columbia — At the Association for Research in Vision and Ophthalmology meeting, Boris Stanzel, MD, discusses a retrospective case ...

Intraoperative Optical Coherence Tomography Demonstrating Macular Hole Associated With Ruptured Retinal Arterial Macroaneurysm  Healio

Ophthalmic Surgery, Lasers and Imaging Retina | A 67-year-old female presented with vitreous hemorrhage and sub-internal limited membrane (ILM) ...

Combined central retinal vein, central retinal artery and cilioretinal | IMCRJ  Dove Medical Press

Combined central retinal vein, central retinal artery and cilioretinal artery occlusion with ischemic macular hole secondary to severe orbital cellulitis after black fly ...

Current Management of Macular Hole  Healio

Ophthalmic Surgery, Lasers and Imaging Retina | Seenu M. Hariprasad, Practical RetinaCo-Editor In this issue's Practical Retina column, Sumit Randhir Singh, ...

Plasma rich in growth factors showed success in macular hole closure  Healio

FORT LAUDERDALE, Fla. — The use of plasma rich in growth factors for recurrent macular hole closures in a pilot study showed success in two patients over a ...

Vitreoretinal Surgery Devices Market Size, Share & Trends Analysis Report with Top Players Like Allen Medical Systems, Abbott Laboratories, Covidien, Mediland Enterprise, Merivaara, Wallach Surgical Devices, Sunnex MedicaLights  Healthcare News

The “Global Vitreoretinal Surgery Devices Market” provides up-to-date information on current and future industry trends, enabling readers to identify products ...

Lamellar macular hole surgery – current concepts, future prospects | OPTH  Dove Medical Press

Lamellar macular hole surgery - current concepts, future prospects Christos Haritoglou,1 Ramin Tadayoni,2 Jean-Pierre Hubschman3 1Herzog Carl Theodor ...

Retinal Drugs And Biologics Market to Offer Lucrative Growth Prospects for Manufacturers by 2027 |ALLERGAN, Alimera Sciences  Wiki Times

Retina is a very sensitive and delicate part of human eye which is responsible for receiving and processing light to convert into neural signals and send to the ...

Study finds predictors of visual outcomes following vitrectomy for macular hole  Healio

Poor preoperative visual acuity, perioperative complications, age-related macular degeneration and delay to surgery are significant predictors of final visual ...

Macular Hole Formation After Pars Plana Vitrectomy for Diabetic Tractional Retinal Detachment  Healio

Ophthalmic Surgery, Lasers and Imaging Retina | BACKGROUND AND OBJECTIVE:To investigate the incidence, clinical features, and outcomes of patients with ...

IRIDEX's MicroPulse® Laser Technology Featured in Several Glaucoma and Retina Research Presentations at Major Ophthalmic Industry Conferences  Associated Press

Press release *content* from Globe Newswire. The AP news staff was not involved in its creation.

Autologous retinal transplant successfully closes refractory macular holes  medwireNews

Autologous neurosensory retinal transplantation results in the closure of full thickness macular holes in the vast majority of patients for whom.

Biocompatible film promotes retinal break repair, macular hole closure  Healio

VANCOUVER, British Columbia — A new technique involving a novel biocompatible film can resolve interruption of retinal tissue with a regenerative process, ...

Predictors of Visual Acuity Outcomes Following Vitrectomy for Idiopathic Macular Hole  Healio

Ophthalmic Surgery, Lasers and Imaging Retina | BACKGROUND AND OBJECTIVE:To investigate predictors of visual outcomes in patients who underwent ...

Optical coherence tomography angiography features in patients with idi | CIA  Dove Medical Press

Optical coherence tomography angiography features in patients with idiopathic full-thickness macular hole, before and after surgical treatment Tomasz ...

Updated Cost-Effectiveness of Intravitreal Ocriplasmin for Vitreomacular Adhesion and Macular Hole  Healio

Ophthalmic Surgery, Lasers and Imaging Retina | BACKGROUND AND OBJECTIVE:The purpose of this study is to provide an updated assessment of ...

Healthy Living: Macular Hole  WABI

BANGOR, Maine (WABI) Treatment of Macular Hole Healthy Living - August 14, 2018. Michael Johnson, MD - Eastern Maine Medical Center. The inverted ...

Repeat Surgery in Failed Primary Vitrectomy for Macular Holes Operated With the Inverted ILM Flap Technique  Healio

Ophthalmic Surgery, Lasers and Imaging Retina | BACKGROUND AND OBJECTIVE:Effects of repeat surgery in failed primary full-thickness macular hole ...

Vitreoretinal Surgery Devices Market Projected for Promising Growth till 2029  Kentucky Journal 24

Vitreoretinal surgery devices are specialized surgery devices utilized in the vitrectomy procedure and in the repair of the detached retina of the eye.

Global conference on retinal care and ophthalmic services  The New Indian Express

The ninth edition of Reticon, an annual conference on retina surgery, was organised by Dr Agarwal's Eye Hospitals, on Sunday at ITC Grand Chola, Guindy.

Relationship Between Metamorphopsia and Macular Parameters Before and After Idiopathic Macular Hole Surgery  Healio

Ophthalmic Surgery, Lasers and Imaging Retina | BACKGROUND AND OBJECTIVE:To investigate changes in the pattern of metamorphopsia in patients after ...

Patient Recovery Chair Market: Global Industry Trend Analysis 2013 to 2017 and Forecast 2018 – 2026  Digital Day News

Patient recovery chair provides a posture that is necessary during a surgical procedure. Patient recovery chairs omit a series of negative consequences such as ...

Worldwide Retinal Pharmaceuticals Market Forecast 2019-2024 Growth Drivers, Regional Outlook  News by Decresearch

Market Study Report, LLC, has added an exhaustive research study of the ' Retinal Pharmaceuticals market', detailing every single market driver and intricately ...

Surgical Repair of Traumatic Macular Holes With Extreme Macular Pathology Using an Internal Limiting Membrane Flap Technique  Healio

Ophthalmic Surgery, Lasers and Imaging Retina | This report describes the use of inverted internal limiting membrane (ILM) flap technique as a treatment option ...

Incidence and prevalence of vitreomacular traction with and without ma | OPTH  Dove Medical Press

Incidence and prevalence of vitreomacular traction with and without macular hole in Germany Jacob Menzler,1 Aljoscha Steffen Neubauer,1,2 Christos ...

Retinal Surgery Devices Market will hit USD 2.1 Bn by 2021  B2B News Updates

The Market Research Group Announced The Analysis Report “Retinal Surgery Devices Market (Retinal Laser Equipment, Microscopic Illumination Equipment, ...

Inverted ILM flap technique closes large macular holes  Healio

An inverted internal limiting membrane flap technique for the treatment of large macular holes offered a higher incidence of type 1 closure with improved ...

Autologous retinal transplants are 'true transplants' for macular holes  Healio

NEW ORLEANS — Autologous retinal transplants for macular holes provide “true transplants” and are not just plugs, according to a speaker here. “With the ...

Retinal Pharmaceuticals Market booming by 2019: Global Sales, Revenue and Market Share by Countries estimate to 2024  The Warren Daily

Global Retinal Pharmaceuticals market 2024- report describes the vital development factors, opportunities and market share of top players during the forecast ...

Rodney P. Coe, MD, Ophthalmologist -Retina Surgeon with the Retina Group of New York  Fast News Media

(FastNewsMedia Editorial):- New York City, May 3, 2019 (Issuewire.com) – Dr. Rodney P. Coe is a physician with the Retina Group of New York, who has served ...

A Laser Pointer Burned a Hole in a 9-Year-Old Boy's Eye, Doctors Say  TIME

A laser pointer caused a macular hole in the left eye of a nine-year-old Greek boy, according to the New England Journal of Medicine.

Laser pointer burns hole in boy’s retina  wreg.com

A 9-year-old boy in Greece permanently injured his left eye when he repeatedly gazed into a laser pointer's green beam, doctors say.

Surgical outcomes differ depending on type of lamellar macular hole  Healio

Patients with lamellar macular holes with lamellar hole-associated epiretinal proliferation tend to have worse visual outcomes compared with patients who have ...

Global Retinal Surgery Devices Market 2019 Primary and Secondary Research, Product Research, Investment Overview, Size and Forecast by 2025  Market Research Gazette

The global retinal surgery devices market is likely to exceed US$ 3 Billion by 2025, almost double from its level in 2017. Various retinal surgery devices segment ...

Global Retinal Disorders Treatment Market: Key companies Profile, their market Share and other important parameters  Market Research Publisher

Global Retinal Disorders Treatment Market Report is the new offering at 'The Market Reports' which covers key company profile, their market share and other ...

Retinal Surgery Devices Market Size, Share & Trends Analysis Report with Top Players Like Alcon, Bausch & Lomb, Iridex, Synergetics USA, ASICO, Beaver-Visitec International, Biotech Visioncare  Healthcare News

The “Global Retinal Surgery Devices Market” provides up-to-date information on current and future industry trends, enabling readers to identify products and ...

Global Retinal Disorders Therapy Market Report to Share Key Aspects of the Industry with the details of Influence Factors  Market Research Publisher

Global Retinal Disorders Therapy Market offers a wide range of market dynamics like current trends (2019), estimated forecast (2025), segmentation by types, ...

Top stories from Retina World Congress  Healio

The Retina World Congress was held in Fort Lauderdale, Florida, from March 21 to 24. Here are the top five most-read articles or most-watched video interviews ...

Retinal Pharmaceuticals Market Growth Is Skyrocketing Beyond Predictions  Market Research Gazette

Retinal Pharmaceuticals is primarily used to treat retinal-related diseases. Retina is a layer of nerve tissue lining the back of the eye. Retina receives light and ...

Vitreous Tamponades Market: Global Industry Insights, Trends And Outlook 2026 | Alcon, Carl Zeiss Meditec AG, Fluoron GmbH, DORC Dutch Ophthalmic Research Center BV  openPR

Vitreous tamponades are essentials used in vitrectomy procedures for healing or reattachment of retina and in vitreous dysfunction. They are majorly used in ...

Autologous retinal transplantation used to treat macular hole  Healio

Patients who have undergone multiple failed procedures to close macular holes may benefit from a new autologous retinal transplantation technique, according ...

EyeMax Mono IOL shows promise in patients with macular disease  Healio

Visual acuity improved in patients with geographic atrophy who underwent cataract surgery and implantation of a novel monofocal IOL in the capsular bag, ...

Global Retinal Disorders Treatment Market Report to Share Key Aspects of the Industry with the details of Influence Factors  Premier Herald

Global Retinal Disorders Treatment Market Report is the new offering at 'The Market Reports' which covers key company profile, their market share and other ...

Foveal Avascular Zone Area Analysis in Macular Hole Before and After Surgery Using Optical Coherence Tomography Angiography  Healio

Ophthalmic Surgery, Lasers and Imaging Retina | BACKGROUND AND OBJECTIVE:To analyze the foveal avascular zone (FAZ) area in superficial and deep ...

Macular hole causes blindness, Optometrist warns  The Eagle Online

Dr Progress Oyegbeda, the Chief Medical Director, Clear Vision Eye Clinic in Bayelsa, has warned that macular hole in the eyes could lead to blindness, if not ...

Ala Moshiri  The Conversation US

I am a clinician scientist working as an ophthalmologist and retina surgeon, as well as an laboratory basic scientist researcher studying genetics of eye disease.

Disorganization of retinal inner layers may be biomarker for macular surgery outcomes  Healio

FORT LAUDERDALE, Fla. — Patients with idiopathic epiretinal membranes and severe disorganization of retinal inner layers did not experience significant ...

VIDEO: Gene therapy advances in inherited retinal disease, AMD, optogenetics  Healio

WAIKOLOA, Hawaii ― Elias Reichel, MD, discusses the latest advances in gene therapy for inherited retinal diseases, age related macular degeneration and ...

Impressive growth of Vitrectomy Devices Market Progresses for Huge Profits by 2025 with Focusing Key players like Alcon, Bausch & Lomb, Carl Zeiss Meditec AG  Market Research Updates

The Vitrectomy Devices Market research report we have published is an accurate statement for any company to rely on to kickstart industry Vitrectomy Devices ...

Vitrectomy Devices Market In-depth Survey Report 2019 to 2025  Market Research Periodical

The report provides a unique tool for evaluating the Market, highlighting opportunities, and supporting strategic and tactical decision-making. This report ...

VIDEO: Pearls on retinal detachment surgery  Healio

FORT LAUDERDALE, Fla. At the Retina World Congress, Kourous A. Rezaei, MD, discusses pearls on retina detachment surgery, such as the use of chandelier ...

First patient dosed in Ocular Therapeutix wet AMD trial  Healio

The first patient has been dosed in a phase 1 clinical trial of OTX-TKI for patients with wet age-related macular degeneration, according to a press release from ...

Increase in choroidal thickness seen after CPAP therapy  Healio

Patients with obstructive sleep apnea syndrome who underwent continuous positive airway pressure therapy experienced an increase in choroidal thickness ...

Vitrectomy yields more macular hole closures than Jetrea  Healio

BOSTON — Visual outcomes were similar in eyes with bilateral macular holes that underwent a vitrectomy or intravitreal ocriplasmin injection, but primary ...

vitreoretinal surgery devices market trends:Constantly Increasing Prevalence of Retinal Disorders  Market Research Gazette

Vitreoretinal surgery devices are specialized surgery devices utilized in the vitrectomy procedure and in the repair of the detached retina of the eye.

Three trials show efficacy of suprachoroidal CLS-TA injections for macular edema in uveitis  Healio

FORT LAUDERDALE, Fla. — Three clinical trials demonstrated rapid and sustained reduction of macular edema secondary to noninfectious uveitis in patients ...

Rare Eye Symptoms of Alport Syndrome Linked to COL4A4 Mutation in Portuguese Woman  Alport Syndrome News

Read more about the case of Portuguese woman with a COL4A4 mutation who developed large holes in the retina of both eyes.

VIDEO: Notal Vision pursues home-based OCT for wet AMD monitoring  Healio

CHICAGO — At the Ophthalmology Innovation Summit at AAO, Quinton Oswald, CEO of Notal Vision, discusses the company's pursuit of an OCT home ...

Vitreoretinal Surgery Devices Market to Showcase Vigorous Demand during the Period until 2029  New Daily Herald

Vitreoretinal surgery devices are specialized surgery devices utilized in the vitrectomy procedure and in the repair of the detached retina of the eye.

Biologics license application accepted for brolucizumab for wet AMD  Healio

The FDA has accepted a biologics license application for brolucizumab for the treatment of neovascular age-related macular degeneration, Novartis announced ...

First patient dosed in Innovent wet AMD trial  Healio

Innovent Biologics has dosed the first patient in a phase 1 trial of IBI302, the company's wet age-related macular degeneration treatment candidate, according to ...

Surgeons perform first gene therapy procedure aimed at stopping AMD-related blindness  Healio

Researchers have completed the first gene therapy procedure aimed at stopping age-related macular degeneration.The operation was performed at John ...

Laser pointer burns hole in Greece boy’s retina  fox8.com

GREECE – A 9-year-old boy in Greece permanently injured his left eye when he repeatedly gazed into a laser pointer's green beam, doctors say. Examination ...

Two phase 3 trials to investigate faricimab for wet AMD  Healio

Roche and Genentech are initiating two phase 3 global trials to investigate the bispecific molecule faricimab for the treatment of wet age-related macular ...

VIDEO: Topical treatment of AMD shows promise in early stages of clinical trial  Healio

VIENNA — At the Euretina meeting, Hemal Mehta, MD, speaks about the early results of the PanOptica clinical trial on a new molecule for the topical treatment of ...

VIDEO: Oral treatment shows good visual improvement in newly diagnosed wet AMD patients  Healio

FORT LAUDERDALE, Fla. — At the Retina World Congress, Michael W. Stewart, MD, professor and chairman of ophthalmology at the Mayo Clinic in ...

Ocriplasmin not as cost-effective as vitrectomy for vitreomacular adhesion, macular hole  Healio

WAIKOLOA, Hawaii — Jetrea may not be as cost-effective as vitrectomy for vitreomacular adhesion and macular hole closure, a speaker told colleagues here.

Kodiak's investigational anti-VEGF yields positive results  Healio

Kodiak Sciences' drug candidate KSI-301 improved vision, anatomy or both in eight of nine patients with severe diabetic macular edema in a phase 1a trial, ...

Scleral buckling or vitrectomy for primary retinal detachment up to surgeon preference  Healio

WAIKOLOA, Hawaii — Whether to perform scleral buckle alone or add it to pars plana vitrectomy in cases of primary rhegmatogenous retinal detachment is a ...

Visual recovery possible after eye injuries from hand-held laser pointers  Healio

Commercial hand-held laser pointers can inflict macular injuries, but good visual recovery is possible. A study included eight eyes of seven patients who ...

Saving sight without surgery: Macular holes  WFTV Orlando

BACKGROUND: A macular hole is a small break in the macula, the center of the eye's light-sensitive tissue called the retina.

Twice weekly fish intake reduces risk of AMD  Healio

A diet that includes eating fish twice a week as well as daily intake of fruits and vegetables was associated with reduced risk of developing age-related macular ...

Social cost of retinal blindness in US will be billions of dollars by 2020  Healio

FORT LAUDERDALE, Fla. — The direct, indirect, and intangible costs due to neovascular age-related macular degeneration, diabetic macular edema, and ...

LumiThera receives $2.5 million grant to study dry AMD treatment option  Healio

LumiThera has received a $2.5 million small business innovative research phase II grant from the National Institute of Health and the National Eye Institute to ...

Vitreoretinal Surgery Devices Market: The vitreoretinal surgery devices market is expected to expand at a 6.0% CAGR in terms of value over 2019-2029.  Digital Day News

Vitreoretinal surgery devices are specialized surgery devices utilized in the vitrectomy procedure and in the repair of the detached retina of the eye.

Is postoperative face-down positioning necessary after pars plana vitrectomy for repair of full-thickness macular hole?  Healio

Perspective. Face-down positioning is never necessary, regardless of hole size, and is extremely difficult for many patients in this age group. Our practice has ...

Vascular Density of Retinal Capillary Plexuses in Different Subtypes of Macular Hole  Healio

Ophthalmic Surgery, Lasers and Imaging Retina | BACKGROUND AND OBJECTIVE:To compare vessel density and the foveal avascular zone (FAZ) area ...

At 1 year, aflibercept injections did not impact CNV conversion rates  Healio

FORT LAUDERDALE, Fla. — Patients with intermediate age-related macular degeneration treated with intravitreal aflibercept injections did not experience ...

MAPLE trial shows less intraocular inflammation after abicipar use  Healio

There was a decrease in the incidence of intraocular inflammation in the 28-week MAPLE study of abicipar pegol, Allergan and Molecular Partners announced ...

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Alport Syndrome and Vision  Alport Syndrome News

Alport syndrome, a genetic disorder, leads to kidney disease, hearing loss, and eye abnormalities. Eye issues are usually diagnosed in middle age or later.

Corticosteroid implant shows positive real-world outcomes in severe cases of DME  Healio

VIENNA — Real-world 3-year data from the RETRO-IDEAL study showed that advanced diabetic macular edema cases can benefit from being treated with the ...

IND application accepted for Aerie's AR-1105  Healio

The FDA has accepted an investigational new drug application for AR-1105, a treatment candidate for macular edema due to retinal vein occlusion, Aerie ...

Notal Vision's home-based OCT system granted breakthrough device designation  Healio

The FDA has granted breakthrough device designation to Notal Vision's home-based OCT system, according to a press release.The artificial intelligence-based ...

UCSD Doctor Who Violated Human Research Rules 'On Leave' Following Inewsource Investigation  KPBS

Dr. Kang Zhang, chief of eye genetics at the University of California, San Diego, is “on leave” after an inewsource investigation exposed how the doctor put ...

Patients with Alzheimer's exhibit significant changes in retinal microvasculature  Healio

When compared with patients with mild cognitive impairment and control subjects, patients with Alzheimer's disease exhibited significantly reduced macular ...

UCSD eye doctor Kang Zhang 'on leave' following investigation into human research violations  inewsource

UCSD Kang Zhang is “on leave” after an inewsource investigation exposed how the eye doctor put medical research subjects in harm's way.

This Is The Horrifying Reason You Should Never Stare Into a Laser Pointer  ScienceAlert

If you've ever wondered why you shouldn't direct a laser pointer at your eyes, let a 9-year-old boy in Greece be your cautionary tale: by repeatedly staring into a ...

FDA places clinical hold on IND application for Adverum's wet AMD gene therapy  Healio

The FDA has placed a clinical hold on Adverum Biotechnologies' investigational new drug application for its gene therapy candidate for wet age-related macular ...

VIDEO: Large cohort shows safety of Ozurdex for DME  Healio

VIENNA ― At the Euretina meeting here, Jay Chhablani, MD, discusses safety results of a large cohort of patients with diabetic macular edema treated with ...

Oxurion completes phase 2 enrollment for anti-PlGF, anti-VEGF combination therapy for DME  Healio

Enrollment is complete in a phase 2 trial of the anti-PlGF THR-317 in combination with the anti-VEGF ranibizumab for the treatment of diabetic macular edema, ...

BioTime, Orbit Biomedical to collaborate on OpRegen subretinal delivery for dry AMD  Healio

BioTime has entered into a research and option agreement with Orbit Biomedical regarding technology to deliver OpRegen to treat dry age-related macular ...

Dexamethasone implant for macular edema improves VA, CRT  Healio

Patients with macular edema who received a dexamethasone intravitreal implant experienced significantly improved best corrected visual acuity and central ...

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Health Canada approves Iluvien for DME  Healio

Iluvien has been approved by Health Canada, Alimera Sciences announced in a press release.A fluocinolone acetonide sustained-release intravitreal implant, ...

Phase 3 trials to focus on Port Delivery System for AMD, faricimab for DME  Healio

Genentech and Roche announced the initiation of three large phase 3 clinical trials evaluating the Port Delivery System with ranibizumab to treat wet ...

First patient dosed in Adverum wet AMD gene therapy trial  Healio

The first patient has been dosed in a phase 1 trial of ADVM-022 gene therapy for wet age-related macular degeneration, Adverum Biotechnologies announced ...

Access to retina providers shows no geographic bias in US  Healio

PHILADELPHIA — Access to retina care in the United States shows no geographic bias, a study found. A retrospective cross-sectional review of a 2016 ...

Novel anti-VEGF for wet AMD meets safety, tolerability endpoint  Healio

WAIKOLOA, Hawaii — Sunitinib, a novel intravitreal anti-VEGF delivered via a biodegradable depot for extended treatment of neovascular age-related macular ...

BLOG: Conditions that can be exacerbated by cataract surgery  Healio

Optometry Blogs | Halvorson Bronner | Our last blog looked primarily at macular sources of reduced acuity that are frequently seen in a cataract patient and ...

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