Central Serous Retinopathy

Central serous retinopathy causes central vision loss secondary to fluid leaking under the center of the macula.

What is a Central Serous Retinopathy?

Moderate central vision loss in men (90% of these cases are men) aged 40 to 60 is sometimes caused by central serous retinopathy. Central serous retinopathy is caused by excessively leaky blood vessels in the choroid which is the layer of blood vessels under the retina. When these vessels become excessively leaky, fluid builds up in the choroid and some of that fluid can break through the barrier of the retinal pigment epithelium. The retinal pigment epithelium is a single layer of cells under that retina that are water tight. The fluid that breaks through the retinal pigment epithelium builds up under the retina forming a blister of fluid under the retina. This fluid blurs the vision in two ways. First, because the retina is elevated away from the retinal pigment epithelium by the fluid, it does not receive nutrients and oxygen as efficiently as it should and it doesn't work well. Second, because the retina is not where it should be, images become out of focus. Some people with central serous retinopathy will notice if they wear reading glasses, they can see better because the reading glasses can sometimes refocus the image on the elevated retina.

Cause of Central Serous Retinopathy

The animated image shows a classic smokestack on fluorescein angiography in a patient with acute central serous retinopathy. The white trace dye, fluorescein, does not leak out of the pigment epithelium under the retina. In patients with central serous retinopathy, there is leakage in the choroid of fluid that builds up and then pushes through the barrier layer under the retina, the retina pigment epithelium. That shows up as a leaky spot on the fluorescein angiogram. Because of the concentration gradient in the subretinal fluid, the fluorescein dye moves up from the leaky spot and forms a smokestack looking white are under the center of the macula.

Central Serous Retinopathy and Fundus Autofluorescence

There are several tests that can be done to establish the diagnosis of central serous retinopathy and to help guide management. Fundus autofluorescence - in the accompanying photograph, show the area of bright autofluorescence from the serous retinal detachment. The photoreceptor outer segments that accumulate in the serous retinal detachment autofluoresce and show up bright in the image. Also optical coherence tomography can show the choroidal thickening and the subretinal fluid. Fluorescein angiography and indocyaning green angiography will show which areas of the choroid are leaking and can help guide treatment.

Who develops Central Serous Retinopathy

Central serous retinopathy is associated with Type A personality. Ninety percent of cases occur in men. It is also sometimes seen in people taking steroids orally or by nasal spray. It can also be associated with pregnancy. Serous retinal detachments like those seen in central serous retinopathy can also seen in patients with severe high blood pressure, age related macular degeneration, and posterior uveitis.

The diagnosis of central serous retinopathy is usually established with optical coherence tomography, fluorescein angiography, and sometimes indocyanine green angiography.

Visual acuity usually returns to normal within about 6 months (sometimes sooner) in 95 percent of affected patients. The recurrence rate is 25 percent. If vision does not recover in a reasonably amount of time, hot laser, photodynamic therapy (cold laser) can be considered.

What is Chronic Central Serous Retinopathy

There are some patient who develop chronic central serous retinopathy. Those patients have subretinal fluid for more than 6 months. Sometimes subretinal fluid will persist for years. In those situations, the chronic subretinal fluid causes damage to the pigment epithelium and the overlying retina. Vision loss gradually develops. When a patient is treated for chronic subretinal fluid, even when the fluid goes away, there is often residual vision loss. Sometimes, with treatment, the vision loss can be stabilized or slowed. The accompanying image shows gutters where the chronic subretinal fluid tracks down due to gravity and causes damage that is visible with testing.

Central Serous Retinopathy Treatment

Very few patients with central serous retinopathy require treatment. 90% of patients improve without therapy. Sometimes, central serous retinopathy becomes chronic and causes vision loss that does not improve. Focal laser treatment to the leaking spot is usually effective in patients with CSR. More commonly, photodynamic laser with visudyne is used to treat CSR. Photodynamic laser is a very low power laser which is used to activate the visudyne. The visudyne is infused intravenously over 10 minutes then a 5 minute washout period is observed. Then 86 seconds of laser (low enegery) is used to activate the the drug and seal up the leaky areas in the choroid. This treatment is usually effective. It is likely safer than focal laser but does sometimes need to be repeated.

Central Serous Retinopathy NEWS

Below are current articles from a Google News Feed on Central Serous Retinopathy

Clinical spectrum of severe chronic central serous chorioretinopathy a | OPTH  Dove Medical Press

Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy Danial Mohabati,1,2 Elon HC van Dijk,1 Thomas J ...

Half-dose PDT resolves subretinal fluid in chronic central serous chorioretinopathy  Healio

Half-dose photodynamic therapy for the treatment of chronic central serous chorioretinopathy had superior results when compared with high-density ...

Central serous retinopathy and hand-foot-mouth disease: coincidence or | IMCRJ  Dove Medical Press

Central serous retinopathy and hand-foot-mouth disease: coincidence or causation? Selina Taylor,1 Maureen Khan,2 Shams Zaidi,3 Umair Alvi,4 Yaqoot ...

Atezolizumab with or without cobimetinib versus regorafenib in previously treated metastatic colorectal cancer (IMblaze370): a multicentre, open-label, phase 3, randomised, controlled trial  The Lancet

Microsatellite-stable metastatic colorectal cancer is typically unresponsive to immunotherapy. This phase 3 study was designed to assess atezolizumab plus ...

BALVERSA™ (erdafitinib) Receives US FDA Approval for the Treatment of Patients with Locally Advanced or Metastatic Urothelial Carcinoma with Certain FGFR Genetic Alterations  BioSpace

HORSHAM, Pa., April 12, 2019 /PRNewswire/ -- The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that BALVERSA™ ...

Predictors of Outcome During Eplerenone Therapy in Chronic Central Serous Chorioretinopathy:A Prospective, Open-Label Pilot Clinical Study  Healio

Ophthalmic Surgery, Lasers and Imaging Retina | BACKGROUND AND OBJECTIVE:To assess the treatment response and predictive factors following ...

BLOG: How do eplerenone and spironolactone treat CSCR?  Healio

Optometry Blogs | Doug Rett, OD, FAAO | In December, Primary Care Optometry News quoted me in an article about central serous chorioretinopathy. The article ...

Clinical characteristics and long-term visual outcome of severe phenot | OPTH  Dove Medical Press

Clinical characteristics and long-term visual outcome of severe phenotypes of chronic central serous chorioretinopathy Danial Mohabati,1,2 Thomas J van ...

Patients respond differently to central serous retinopathy treatment  Healio

WASHINGTON – A multitude of management options exist for central serous retinopathy, and “if the patient doesn't become better in 3 to 4 months, consider ...

Long-term outcomes in half-dose verteporfin photodynamic therapy for c | OPTH  Dove Medical Press

Long-term outcomes in half-dose verteporfin photodynamic therapy for chronic central serous retinopathy Nadeem Ali Dhirani,1 Yelin Yang,2 Sohel Somani2–4 ...

VIDEO: Role of OCT angiography in central serous chorioretinopathy  Healio

At Retina 2016, Jay S. Duker, MD, discusses the use of OCT angiography in patients with central serous chorioretinopathy.

Persistent stress may lead to vision loss, study shows  Medical News Today

A new analysis of existing studies shows that persistent psychological stress can lead to conditions such as glaucoma, retinal neuropathy, and vision loss.

Characteristics of the Choriocapillaris Layer in Optical Coherence Tomography Angiography of Acute Central Serous Chorioretinopathy  Healio

Ophthalmic Surgery, Lasers and Imaging Retina | BACKGROUND AND OBJECTIVE:To describe the vascular characteristics of the choriocapillaris layer in acute ...

PDT should be considered for chronic central serous chorioretinopathy  Healio

WAILEA, Hawaii — Retina specialists should consider photodynamic therapy as an adjunctive treatment for chronic central serous chorioretinopathy, according ...

Half-dose verteporfin PDT increases visual acuity, reduces recurrence in central serous chorioretinopathy  Healio

COLORADO SPRINGS, Colo. — Photodynamic therapy with half-dose verteporfin significantly increased visual acuity in eyes with central serous ...

Increase in choroidal thickness seen after CPAP therapy  Healio

Patients with obstructive sleep apnea syndrome who underwent continuous positive airway pressure therapy experienced an increase in choroidal thickness ...

Central Serous Chorioretinopathy: Risk Factors Identified  Medscape

H pylori infection, steroid use, disturbed sleep, autoimmune disease, psychopharmacologic medication use, and type A behavior were among possible risk ...

Betrayal comes full circle, says a Salt Lake City gang investigator who developed PTSD, then lost his job  Salt Lake Tribune

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How a turmeric compound could treat glaucoma  Medical News Today

Glaucoma can lead to vision loss, but a turmeric derivative can improve current treatments. New research devises a viable method of adding it to eye drops.

Photodynamic Therapy Market 2026: Top Key Players IPI SINGAPORE, DUSA Pharmaceuticals, Inc  Titan Chronicle

Special drugs like certain photosensitizing agents are used with light to kill malign cancerous cells in a photodynamic therapy. These type of drugs are efficiently ...

BLOG: Laser still has an important role in diabetic eye disease  Healio

Ophthalmology Blogs | Mali | There is no question that the introduction of anti-VEGF agents has dramatically changed the landscape of how surgeons approach ...

Questions remain about use of 'nondamaging' retinal laser therapies  Healio

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Ophthalmology Conference: International Retinal Imaging Symposium (IntRIS 2019) - Los Angeles March 16, 2019  MD Linx

The International Retinal Imaging Symposium (IntRIS 2019) will feature a series of lectures devoted to advanced retinal imaging and the newest developments ...

ESPN's Britt McHenry says she feared for her life, had health issues after viral rant  The Washington Post

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New risk factors for retinal disorder identified  EurekAlert (press release)

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Trump-induced anxiety is so bad my eye started bleeding  New York Daily News

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Researchers use heart drug to treat eye disease in groundbreaking study  Medical Xpress

Researchers in Southampton are leading a groundbreaking study into whether or not a drug used to treat heart failure could save the sight of patients with a ...

Half-dose or half-time PDT improves visual acuity, reduces subretinal fluid  Healio

Half-dose and half-time fluorescein angiography-guided photodynamic therapy yielded similar visual and anatomic results in the treatment of central serous ...

Treating Central Serous Retinopathy: Adjunctive Nutritional Management  Dynamic Chiropractic

Central serous retinopathy (CSR), or central serous chorioretinopathy (CSC), is an eye disease that causes visual impairment. The condition is often temporary, ...

Safety, Tolerability Increases Post-Bevacizumab Injection in Intraocular Pressure  MD Magazine

New research has shown that increased IOP is tolerable to corneal endothelium, and safe for most patients' eyes despite immediate increases post-injection.

Erdafitinib Active in Advanced Metastatic Urothelial Carcinoma  OncLive

More than 40% of patients with metastatic or unresectable urothelial carcinoma responded to treatment with an investigational fibroblast growth factor receptor ...

Jarrod Lyle going through heartbreaking rough patch in cancer fight  Golfweek

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Global Optical Coherence Tomography (OCT) Market Outlook 2017-2026 - Insufficient Clinical Data and Lack of Reimbursement Facilities are Inhibiting the Market Growth  GlobeNewswire

Dublin, Feb. 14, 2019 (GLOBE NEWSWIRE) -- The "Optical Coherence Tomography (OCT) - Global Market Outlook (2017-2026)" report has been added to ...

New treatment avenue to prevent serious retinal detachment  Science Daily

Wet age-related macular degeneration (AMD) is the leading cause of severe vision loss in older individuals. AMD and other serious chronic eye problems that ...

Heart failure drug could save the sight of patients with once-untreatable eye condition  Express

A DRUG used to treat heart failure is at the centre of a £1 million study to establish whether it can save the sight of patients with a currently untreatable eye ...

Challenges of Treating Irregular Astigmatism: Ophthalmology Times  MedPage Today

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Easy on the Eyes: Protecting Eye Health Through Cancer Treatments  Curetoday.com

CAROLYN CHOATE, A 15-YEAR survivor of stage 3b breast cancer, fully expects to live for a long time to come. However, an ongoing eye problem presents a ...

Why you should nap your way to the top  New Zealand Herald

Overflowing inbox, unattended voicemails, a growing to-do list and the sense that the day is slipping through your fingers. The mid-afternoon slump kicks in just ...

What your eyes can say about your health  Livemint

The eyes are a good place to look for signs of trouble brewing in the body. An eye check-up is, in fact, a relatively inexpensive way of doing so (a comprehensive ...

NSAIDs Speed Central Serous Choroidopathy Recovery  Medscape

NEW ORLEANS — Patients with central serous choroidopathy treated with nonsteroidal anti-inflammatory drug (NSAID) eyedrops recover faster than when they ...

Moorfields Dubai offers advanced treatment for retinal conditions  Trade Arabia

Moorfields Eye Hospital Dubai, the first overseas branch of the Moorfields London hospital, has introduced a new advanced treatment for retinal conditions ...

When I Thought I Was Going Blind, a Second Opinion Changed My Life  Reader's Digest

It took a doctor who really listened to my symptoms to figure out my actual diagnosis.

Proliferative diabetic retinopathy revealed using OCT angiography  Healio

Diabetic retinopathy is one of the leading causes of vision loss worldwide. Uncontrolled blood glucose levels damage retinal vasculature. Anyone with diabetes ...

Macular degeneration may respond to new laser therapy A new study shows how a new type  Medical News Today

A new type of laser treatment has the potential to slow progression of age-related macular degeneration - a major cause of vision loss - without damaging the ...

India- Optical Coherence Tomography Market Report to Grow at a CAGR of 11.7% by 2024 with Analysis by Type, Technology, Application, Size, Share, Growth Rate, End-User, Geography  MENAFN.COM

(MENAFN - GetNews) Global Optical Coherence Tomography Market, By Type (Catheter Based OCT Device, Doppler OCT Devices, Handheld OCT Devices, ...

How to manage solar retinopathy caused by viewing the eclipse  Healio

Today, the U.S. is watching a total eclipse, and many may not be taking the necessary precautions for safe viewing. Jerome Sherman, OD, FAAO, provides tips ...

Responses in Advanced Urothelial Carcinoma With FGFR Inhibitor  Targeted Oncology

According to a phase II study, over 40% of patients with metastatic or unresectable urothelial carcinoma responded to treatment with erdafitinib.

ASCO 2018: Nonimmunotherapy Strategies in Advanced Bladder Cancer  UroToday

ASCO 2018 non-immunotherapy strategies in advanced and metastatic bladder urothelial cancer, immune-checkpoint inhibitors, current standard of care for ...

Janssen Plans Year-End Erdafitinib Filing Based on Phase II Data in FGFR-Mutated Bladder Cancer  GenomeWeb

NEW YORK (GenomeWeb) – Janssen will pursue US marketing approval for the FGFR inhibitor erdafitinib after a Phase II study showed the drug shrunk tumors ...

Elderly man has central vision loss, lipofuscin accumulation  Healio

A 74-year-old Caucasian man presented with a chief complaint of bilateral and symmetric progressive decrease in central vision over the last 2 years.

High-tech 3D optical test free at BMC Eye Center  Manila Bulletin

Malolos City, Bulacan — The Bulacan Medical Center (BMC) Eye Center now offers optical coherence tomography (OCT) services, a non-invasive imaging test ...

My Hospital Eye or: How I Started to Love iPhoneography  PetaPixel

Professional photographers using their smartphones is just a fad, I thought, but it all came to me sooner than I expected. Some 3 weeks ago I was diagnosed ...

More Ways To Wreck Your Eyes Without Even Thinking About It  Motherboard

Yeah, I did it. I looked. It's not like I haven't looked at the Sun before, and I didn't even properly stare at it, but, like our fearless president, I turned from literally ...

1-year results of combined half-dose photodynamic therapy and ranibizumab for polypoidal choroidal vasculopathy  BMC Blogs Network

To evaluate the efficacy and safety of half-dose photodynamic therapy (PDT combined with ranibizumab for polypoidal choroidal vasculopathy (PCV). PCV is ...

Eye Exams Reveal Health Concerns  Glamour

There's the saying about how your (lovely!) eyes are the windows to your soul, right? But it turns out that those same lovely, lovely eyes may just also offer some ...

Omega-3 Fatty Acids Protect Eyes Against Retinopathy, Study Finds  National Institutes of Health (press release)

Omega-3 polyunsaturated fatty acids protect against the development and progression of retinopathy, a deterioration of the retina, in mice. This is the major ...

Did a Concussion Affect My Eyesight? - Vision Center  Everyday Health

"I'm having trouble seeing out of one eye. My doctor said fluid is building up in the eye, from stress. Could this be related to a concussion I had ten months ago?"

Optical Express names its 'Eye Injury XI' football team  AOP

With the UEFA Euro 2016 tournament in France this week, Optical Express has identified some of the most serious eye health problems suffered by footballers.

Women bosses who say the secret of their success comes from napping on the job  Daily Mail

Manchester bosses Fran Elkinson, 49, and Tally Bookbinder, 45 revealed how their 20 to 40 minutes nap during the work day has enabled them to continue to ...

30 stories of stacked irregular discs to form landmark tower in Stockholm  New Atlas

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Photodynamic Therapy Market Expansion Projected to Gain an Uptick During 2018 – 2028  Digital Day News

Special drugs like certain photosensitizing agents are used with light to kill malign cancerous cells in a photodynamic therapy. These type of drugs are efficiently ...

Meet Britt McHenry, the Fox News Star for Millennials  Washingtonian

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Quantel Medical's Vitra™ PDT Laser Receives CE Mark Approval  PR Newswire

CLERMONT-FERRAND, France, Sept. 12, 2014 /PRNewswire/ -- Quantel Medical today announced CE Mark approval for its Vitra™ PDT photodynamic therapy ...

Woman suddenly loses central vision  Healio

Primary Care Optometry News | A 39-year-old Caucasian woman presented complaining of a dark spot in the central vision of her right eye that began 3 days ...

New iterations of laser trabeculoplasty emerging for glaucoma treatment  Healio

Ocular Surgery News | Three emerging forms of laser trabeculoplasty compare well with established modalities in terms of safety and efficacy, according to a ...

Young man presents with subacute binocular diplopia  Healio

Ocular Surgery News | A 22-year-old otherwise healthy man was referred to the New England Eye Center by his primary care physician for 1 to 2 months of ...

Lessons for the Practicing Ophthalmologist  Medscape

You won't want to miss these highlights of clinical eye research from Wills Eye Hospital.

Young, pregnant woman complains of 'smudge' in vision  Healio

Primary Care Optometry News | A 33-year-old Native American female presented with a chief complaint of a “smudge” in the vision of her right eye, which began ...

Dave Harold has quit snooker because of an eye condition | Daily Star  Daily Star

SNOOKER star Dave Harold has quit the sport because of an eye condition which means he can hardly see the table.

New chemical composition of 'poppers' linked to retinal damage: Harms associated with these recreational drugs should be reassessed, urge researchers  Science Daily

The new chemical composition of the legal high 'poppers' is linked to retinal damage at the back of the eye, finds a small study.

Young woman reports blurry vision in one eye, spots, floaters  Healio

A 29-year-old African American female presented upon referral from a fellow optometrist for retinal evaluation. Her chief complaint was blurry vision in the left ...

BRAFTOVI® (encorafenib) in Combination with MEKTOVI® (binimetinib) and ERBITUX® (cetuximab) or panit  PharmiWeb.com

BOULDER, Colo., March 18, 2019 /PRNewswire/ -- Array BioPharma Inc. (NASDAQ: ARRY) today announced that the National Comprehensive Cancer ...

8 Secrets Your Eyes Reveal About Your Health!  PsychCentral.com

Eight things your eyes reveal about your health gives you 8 solid facts on eye health and your emotional and physical wellness. Do you know these 8 secrets?

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The flotsam and jetsam of the artistic life  Irish Examiner

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Array BioPharma Reports Financial Results for the Second Quarter of Fiscal 2019  PRNewswire

Combination of BRAFTOVI, MEKTOVI and ERBITUX® (cetuximab) demonstrated 15.3 months median overall survival in safety lead-in of the Phase 3 BEACON ...

Prednisone and Glucocorticosteroids Need Eye Injury Warnings: Report  AboutLawsuits.com

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AC Milan's Philippe Mexes' eye injury caused by 'too much time on sunbeds'  Mirror.co.uk

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Encorafenib plus binimetinib prolongs OS for advanced BRAF -mutated melanoma  Healio

CHICAGO — Combination therapy with encorafenib plus binimetinib significantly improved OS compared with vemurafenib or encorafenib alone for patients ...

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A 58-Year-Old Man Presenting With a Cystic Neoplasm of the Testis  Renal and Urology News

A 58-year-old white man with a history of hypertension presented for urologic evaluation for obstructive voiding symptoms and an elevated PSA (3.1 ng/dL).

Woman referred for progressive blurred vision, difficulty with night driving  Healio

Ocular Surgery News | A 55-year-old woman was referred to the New England Eye Center with symptoms of progressive blurred vision and difficulty with night ...

Awards, Posters, and Participation by NECO at Academy 2018 | News  New England College of Optometry

New England College of Optometry (NECO) students, faculty, alumni, professional staff, and residents delivered presentations, posters, research, and lectures ...

BLOG: Do we still need to order fluorescein angiographies?  Healio

I recently helped give a workshop on fundus fluorescein angiography, and I spent a fair amount of the introduction trying to prove to the audience that this was ...

A Validated Phenotyping Algorithm for Genetic Association Studies in Age-related Macular Degeneration  Nature.com

Age-related macular degeneration (AMD), a multifactorial, neurodegenerative disease, is a leading cause of vision loss. With the rapid advancement of DNA ...

Marijuana Compound May Help Stop Diabetic Retinopathy  Science Daily (press release)

A compound found in marijuana won't make you high but it may help keep your eyes healthy if you're a diabetic, researchers say. Early studies indicate ...

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The desert offered an hospitable, sunny, 80-degree morning in early spring. The conversation on the shaded poolside patio of the Renaissance Esmeralda ...

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